Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.57 |
| ▸ | NPC1 | O15118 | 12/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.57 |
| ▸ | PKM | P14618 | 8/20 | 0.57 |
| ▸ | TP53 | P04637 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 2/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.48 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083201 | 0.80 | NR1H4 (0.52) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL493279 | 0.77 | FAAH (0.61) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL2162094 | 0.73 | NPC1 (0.54) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL4034138 | 0.73 | NPC1 (0.65) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL3666186 | 0.73 | ALDH1A1 (0.43) | RAB9ANPC1MAPTALDH1A1TSHR | |
| SCHEMBL6384896 | 0.72 | NPC1 (0.63) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL18078055 | 0.72 | HTT (0.56) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL1424895 | 0.72 | TP53 (0.77) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL3517537 | 0.71 | NPC1 (0.68) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL3667161 | 0.71 | ALDH1A1 (0.59) | RAB9ANPC1SMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | claimed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | claimed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |