Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | F12 | P00748 | 1/20 | 0.48 |
| ▸ | F7 | P08709 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL660788 | 0.78 | NR4A2 (0.68) | L3MBTL1MAPTTDP1BLMRECQL | |
| SCHEMBL26463548 | 0.75 | MAOA (0.48) | L3MBTL1MAPTTDP1BLMRECQL | |
| SCHEMBL10048780 | 0.75 | HDAC3 (0.57) | L3MBTL1MAPTTDP1CYP3A4CYP2C19 | |
| SCHEMBL31374745 | 0.75 | F2 (0.46) | L3MBTL1MAPTTDP1BLMRECQL | |
| Succinamide SCHEMBL27765028 | 0.73 | MAPT (0.44) | L3MBTL1MAPTTDP1BLMRECQL | |
| SCHEMBL1478436 | 0.72 | TDP1 (0.72) | L3MBTL1MAPTTDP1CYP3A4CYP2C19 | |
| SCHEMBL6156726 | 0.72 | TDP1 (0.79) | L3MBTL1MAPTTDP1CYP3A4CYP2C19 | |
| SCHEMBL6923108 | 0.72 | GAA (0.50) | L3MBTL1MAPTTDP1BLMRECQL | |
| Succinamide SCHEMBL28421812 | 0.72 | ALDH1A1 (0.50) | L3MBTL1MAPTTDP1BLMRECQL | |
| SCHEMBL13317140 | 0.71 | CES2 (0.52) | L3MBTL1BLMRECQLF2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139895-A1 | AZA-PYRIDOPYRIMIDINONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116742-A1 | AZA-PYRIDOPYRIMIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-02 | — | — | WO | disclosed |