Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365499 | 0.86 | P4HTM (0.38) | PTPN7MEN1KMT2AKDM4ELMNA | |
| SCHEMBL364408 | 0.85 | ALDH1A1 (0.44) | EGFRMEN1KMT2ANPC1RAB9A | |
| SCHEMBL364900 | 0.85 | PSEN1 (0.39) | EGFRKDM4EMAPK1HTTSMN1; SMN2 | |
| SCHEMBL366150 | 0.85 | KMT2A (0.48) | EGFRSRCPTPN7MEN1KMT2A | |
| SCHEMBL364967 | 0.84 | EGFR (0.49) | EGFRSRCKDM4EHTTHPGD | |
| SCHEMBL366362 | 0.83 | SMN1; SMN2 (0.54) | EGFRSRCMEN1KMT2ANPC1 | |
| SCHEMBL365618 | 0.83 | L3MBTL1 (0.39) | MEN1KMT2ANPC1KDM4ELMNA | |
| SCHEMBL364828 | 0.83 | MCL1 (0.37) | MCL1 | |
| SCHEMBL364973 | 0.82 | KMT2A (0.42) | MEN1KMT2AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL366344 | 0.82 | PSEN1 (0.39) | MEN1KMT2AKDM4EMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |