Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364303 | 0.84 | KMT2A (0.46) | SMN1; SMN2KDM4EMAPK1HTTMAPT | |
| SCHEMBL366151 | 0.83 | EGFR (0.45) | SMN1; SMN2KDM4EMAPK1HTTEGFR | |
| SCHEMBL366361 | 0.83 | S1PR3 (0.52) | SMN1; SMN2KDM4EMAPK1HTTEGFR | |
| SCHEMBL365014 | 0.82 | KDM4E (0.48) | SMN1; SMN2KDM4EHTTEGFRMAPT | |
| SCHEMBL365704 | 0.81 | KMT2A (0.52) | SMN1; SMN2KDM4EHTTNPC1RAB9A | |
| SCHEMBL365565 | 0.81 | KMT2A (0.52) | SMN1; SMN2KDM4EMAPK1HTTMAPT | |
| SCHEMBL364594 | 0.78 | EGFR (0.44) | SMN1; SMN2KDM4EHTTEGFRSRC | |
| SCHEMBL364969 | 0.77 | KDM4E (0.53) | KDM4EMAPK1HTTTP53MAPT | |
| SCHEMBL365408 | 0.76 | ALDH1A1 (0.46) | SMN1; SMN2KDM4EMAPTNPC1RAB9A | |
| SCHEMBL364207 | 0.76 | EGFR (0.47) | SMN1; SMN2KDM4EHTTEGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |