Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CFD | P00746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19759420 | 0.76 | PIK3CD (0.35) | PIK3CDNTRK1 | |
| SCHEMBL6432288 | 0.74 | SMN1; SMN2 (0.36) | HTTL3MBTL1 | |
| SCHEMBL3662694 | 0.73 | PARP1 (0.34) | AURKAPIK3CDNTRK1FFAR1ELANE | |
| SCHEMBL10557945 | 0.70 | PSMD14 (0.45) | PIK3CDNTRK1L3MBTL1 | |
| SCHEMBL8689473 | 0.70 | PIK3CD (0.32) | PIK3CD | |
| SCHEMBL12836123 | 0.69 | P2RX7 (0.40) | CYP2C19FFAR1GAAHTT | |
| SCHEMBL6172465 | 0.69 | TNF (0.56) | GAALARS1 | |
| SCHEMBL27989030 | 0.69 | TNF (0.56) | GAALARS1 | |
| SCHEMBL27980860 | 0.69 | TNF (0.56) | GAALARS1 | |
| SCHEMBL3852477 | 0.68 | LGMN (0.44) | AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152670-A1 | BRIDGED SIX-MEMBERED RING COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008132679-A1 | BRIDGED SIX-MEMBERED RING COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-06 | — | — | WO | disclosed |