Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 8/20 | 0.35 |
| ▸ | GSK3B | P49841 | 8/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12210292 | 0.83 | MAOA (0.41) | MAOAMAOBCDC25BKDM4AKDM4B | |
| SCHEMBL22774228 | 0.80 | MEN1 (0.47) | MAOAMAOBCDC25BCYP11B1CYP11B2 | |
| SCHEMBL4595981 | 0.75 | GSK3B (0.50) | CYP11B1CYP11B2GSK3AGSK3BCDK5 | |
| SCHEMBL12015740 | 0.73 | MAOA (0.39) | MAOAMAOBCDC25BKDM4AKDM4B | |
| SCHEMBL19553107 | 0.73 | CDC7 (0.41) | MAOAMAOBCDC25BKDM4AKDM4B | |
| SCHEMBL12469157 | 0.72 | CHRNB2 (0.41) | MAOAMAOBCDC25BCYP11B1CYP11B2 | |
| SCHEMBL483183 | 0.72 | CDC7 (0.44) | MAOAMAOBCDC25BTSHR | |
| SCHEMBL68595 | 0.71 | CA12 (0.45) | MAOAMAOBCDC25BGSK3BTP53 | |
| SCHEMBL6142143 | 0.71 | CYP11B1 (0.63) | CYP11B1CYP11B2PDE3BPDE3ACYP3A4 | |
| SCHEMBL26102745 | 0.71 | MAOA (0.37) | MAOAMAOBCDC25BKDM4AKDM4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879892-A2 | 2-PYRROLIDONE DERIVATIVES AND THEIR USES FOR THE TREATMENT OF INFLAMMATORY CONDITIONS AND PAIN | XENON PHARMACEUTICALS INC. (CA) | 2008-01-23 | — | — | EP | claimed |
| WO-2006113875-A2 | 2 - PYRROLIDONE DERIVATIVES AND THEIR USES FOR THE TREATMENT OF INFLAMMATORY CONDITIONS AND PAIN | XENON PHARMACEUTICALS INC. (CA) | 2006-10-26 | — | — | WO | claimed |
| US-8957219-B2 | Acetic acid amide derivative having inhibitory activity on endothelial lipase | SHIONOGI & CO., LTD. (JP) | 2015-02-17 | — | — | US | disclosed |
| US-20140288302-A1 | ACETIC ACID AMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY ON ENDOTHELIAL LIPASE | SHIONOGI & CO., LTD. (JP) | 2014-09-25 | — | — | US | disclosed |
| US-20110251386-A1 | ACETIC ACID AMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY ON ENDOTHELIAL LIPASE | SHIONOGI & CO., LTD. (JP) | 2011-10-13 | — | — | US | disclosed |
| EP-2240482-A1 | CYCLIC AZAINDOLE-3-CARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | Sanofi-Aventis (FR) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009095162-A1 | CYCLIC AZAINDOLE-3-CARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2009-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251386-A1 | ACETIC ACID AMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY ON ENDOTHELIAL LIPASE | LIPG, CEL, LIPA | MAOA 458/4885MAOB 568/4885CDC25B 4223/4885 |
| US-20140288302-A1 | ACETIC ACID AMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY ON ENDOTHELIAL LIPASE | LIPG, CEL, FFAR3 | MAOA 473/4885MAOB 536/4885CDC25B 4433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.