Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669184 | 0.94 | AR (0.39) | ARCASRMCHR1 | |
| SCHEMBL648801 | 0.90 | DRD4 (0.46) | ARSLC6A4DRD4SLC6A5MCHR1 | |
| SCHEMBL3666568 | 0.89 | PRKAA2 (0.40) | ARSLC6A4DRD4EPHX2SLC6A5 | |
| SCHEMBL3663526 | 0.87 | AR (0.40) | ARCASRDRD4LIPEEPHX2 | |
| SCHEMBL3667429 | 0.86 | SLC6A4 (0.40) | ARSLC6A4DRD4SLC6A5PRKAA2 | |
| SCHEMBL3665362 | 0.86 | PRKAA2 (0.40) | SLC6A4DRD4EPHX2SLC6A5PRKAA2 | |
| SCHEMBL3665282 | 0.86 | SLC6A4 (0.41) | SLC6A4DRD4SLC6A5 | |
| SCHEMBL3662664 | 0.85 | SLC6A5 (0.46) | SLC6A4DRD4SLC6A5MCHR1KCNH2 | |
| SCHEMBL648723 | 0.83 | CHRM4 (0.48) | ARPRKAA2MCHR1 | |
| SCHEMBL3666017 | 0.83 | PRKAA2 (0.40) | AREPHX2PRKAA2MCHR1UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |