Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 11/20 | 0.39 |
| ▸ | CASR | P41180 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665902 | 0.94 | AR (0.41) | ARCASRMCHR1 | |
| SCHEMBL648723 | 0.90 | CHRM4 (0.48) | ARCHRM4MCHR1CHRM2CHRM1 | |
| SCHEMBL3666017 | 0.89 | PRKAA2 (0.40) | ARCHRM4MCHR1CHRM2CHRM1 | |
| SCHEMBL3802167 | 0.86 | CHRM4 (0.40) | CHRM4MCHR1CHRM2 | |
| SCHEMBL648801 | 0.83 | DRD4 (0.46) | ARCHRM4MCHR1CHRM2 | |
| SCHEMBL3666568 | 0.83 | PRKAA2 (0.40) | AR | |
| SCHEMBL4447886 | 0.81 | AR (0.44) | ARMCHR1 | |
| SCHEMBL4403510 | 0.81 | AR (0.45) | ARMCHR1 | |
| SCHEMBL3663526 | 0.81 | AR (0.40) | ARCASR | |
| SCHEMBL3667429 | 0.80 | SLC6A4 (0.40) | ARMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |