SCHEMBL3664036

SCHEMBL3664036

CCc1c[c]c(C)c(-c2cc(Br)ccc2Cl)c1

nearest known ligand 0.35

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.30
HTT P42858 1/20 0.30
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5086382 0.88 ALDH1A1 (0.33) SMN1; SMN2KDM4EALDH1A1
SCHEMBL5089183 0.77 CETP (0.32)
SCHEMBL3664038 0.73 HTR2A (0.35) CYP1A2CYP2D6CYP2C9CYP2C19RXFP1
SCHEMBL4439962 0.73 MEN1 (0.34) SMN1; SMN2KDM4EALDH1A1
SCHEMBL4428493 0.72 GABRA1 (0.34) CYP1A2RXFP1SMN1; SMN2HTTALDH1A1
SCHEMBL4428500 0.71 CNR1 (0.32)
SCHEMBL5086384 0.71 ALDH1A1 (0.33) SMN1; SMN2KDM4EALDH1A1
SCHEMBL3795481 0.70 ERN1 (0.36) CYP1A2CYP2D6CYP2C9CYP2C19RXFP1
SCHEMBL5138167 0.69 MEN1 (0.36)
SCHEMBL27799393 0.67 HTT (0.34) CYP1A2CYP2D6CYP2C9CYP2C19RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2238133-A2 FUNGICIDAL AMIDES E. I. du Pont de Nemours and Company (US) 2010-10-13 EP disclosed
EP-2121660-A2 FUNGICIDAL AMIDES E. I. Du Pont de Nemours and Company (US) 2009-11-25 EP disclosed
WO-2009094407-A2 FUNGICIDAL AMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-07-30 WO disclosed
WO-2008091580-A2 FUNGICIDAL AMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-31 WO disclosed
EP-1948649-A2 FUNGICIDAL CARBOXAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-30 EP disclosed
WO-2007014290-A2 FUNGICIDAL CARBOXAMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-02-01 WO disclosed