Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PNLIP | P16233 | 2/20 | 0.34 |
| ▸ | ESRRG | P62508 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.34 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666093 | 0.84 | OPRM1 (0.37) | ALDH1A1HPGDTSHRHSD17B10MEN1 | |
| SCHEMBL3666492 | 0.80 | P2RX7 (0.38) | MAPTMEN1KMT2APNLIPOPRM1 | |
| SCHEMBL3666118 | 0.78 | OPRL1 (0.38) | MEN1KMT2AOPRM1P2RX7 | |
| SCHEMBL493639 | 0.74 | MAPT (0.44) | ALDH1A1MAPTMEN1KMT2ANAPEPLD | |
| SCHEMBL493440 | 0.70 | TSHR (0.48) | ALDH1A1HPGDNPC1MAPTTSHR | |
| SCHEMBL1327183 | 0.69 | CHRNB2 (0.39) | NPC1OPRM1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL1328400 | 0.69 | KMT2A (0.38) | ALDH1A1HPGDTSHRHTTMEN1 | |
| SCHEMBL493155 | 0.68 | SMN1; SMN2 (0.50) | MAPTMEN1KMT2ANAPEPLDSMN1; SMN2 | |
| SCHEMBL2308766 | 0.67 | KDM4E (0.42) | ALDH1A1HPGDNPC1TSHRHSD17B10 | |
| SCHEMBL493056 | 0.67 | SLC6A2 (0.37) | OPRM1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | claimed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | claimed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |