Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 12/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PNLIP | P16233 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666093 | 0.94 | OPRM1 (0.37) | P2RX7KDM4EKMT2APNLIPMEN1 | |
| SCHEMBL3666118 | 0.91 | OPRL1 (0.38) | P2RX7KMT2AMEN1TDP1OPRM1 | |
| SCHEMBL3665110 | 0.80 | ALDH1A1 (0.39) | P2RX7KDM4EMAPTKMT2APNLIP | |
| SCHEMBL493717 | 0.75 | GAA (0.43) | MAPTKMT2AMEN1GAATDP1 | |
| SCHEMBL493447 | 0.73 | GAA (0.46) | KDM4EMAPTKMT2AMEN1GAA | |
| SCHEMBL2308766 | 0.73 | KDM4E (0.42) | KDM4ERAB9AOPRM1 | |
| SCHEMBL1326900 | 0.72 | NPC1 (0.41) | MAPTKMT2ARAB9AMEN1 | |
| SCHEMBL1328446 | 0.72 | P2RX7 (0.47) | P2RX7KMT2ARAB9AMEN1GAA | |
| SCHEMBL1326883 | 0.70 | ALDH1A1 (0.44) | KDM4EMAPTKMT2ARAB9AMEN1 | |
| SCHEMBL1327958 | 0.70 | HDAC3 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | claimed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | claimed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |