Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PNLIP | P16233 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666492 | 0.94 | P2RX7 (0.38) | OPRM1P2RX7KDM4EPNLIPMEN1 | |
| SCHEMBL3666118 | 0.92 | OPRL1 (0.38) | OPRM1P2RX7MEN1KMT2ATDP1 | |
| SCHEMBL3665110 | 0.84 | ALDH1A1 (0.39) | OPRM1P2RX7KDM4EALDH1A1HPGD | |
| SCHEMBL2308766 | 0.79 | KDM4E (0.42) | OPRM1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL2306855 | 0.74 | HTR7 (0.45) | P2RX7KDM4EALDH1A1HPGD | |
| SCHEMBL1327800 | 0.72 | HPGD (0.44) | P2RX7ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL493195 | 0.72 | GAA (0.46) | ALDH1A1HPGDTSHRMEN1KMT2A | |
| SCHEMBL1327283 | 0.71 | KCNA3 (0.50) | OPRM1P2RX7KDM4EALDH1A1LMNA | |
| SCHEMBL1326883 | 0.71 | ALDH1A1 (0.44) | OPRM1KDM4EALDH1A1TSHRMEN1 | |
| SCHEMBL1327964 | 0.71 | NPC1 (0.50) | P2RX7KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | claimed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | claimed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |