Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28201939 | 0.83 | GAA (0.44) | GAAMAPTNPC1PKMRAB9A | |
| SCHEMBL3735342 | 0.78 | GAA (0.33) | GAAMAPTNPC1PKMRAB9A | |
| SCHEMBL49612 | 0.77 | GAA (0.52) | GAAMAPTNPC1RAB9A | |
| Phosphine SCHEMBL28142196 | 0.76 | GAA (0.50) | GAAMAPTNPC1RAB9A | |
| SCHEMBL27985279 | 0.75 | MAPK1 (0.40) | GAAMAPTNPC1PKMRAB9A | |
| SCHEMBL27543146 | 0.75 | MTOR (0.34) | GAAMAPTNPC1RAB9A | |
| SCHEMBL8691291 | 0.74 | IDO1 (0.31) | — | |
| SCHEMBL28329121 | 0.73 | GAA (0.47) | GAAMAPTNPC1RAB9A | |
| SCHEMBL11620262 | 0.71 | PIN1 (0.46) | NPC1RAB9A | |
| SCHEMBL23927532 | 0.71 | ADORA2A (0.38) | GAAMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231602-A1 | GAMMA SECRETASE MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009075874-A1 | GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-06-18 | — | — | WO | claimed |
| EP-2231602-A1 | GAMMA SECRETASE MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009075874-A1 | GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-06-18 | — | — | WO | disclosed |