Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28201939 | 0.85 | GAA (0.44) | GAAMAPTNPC1PKMRAB9A | |
| SCHEMBL27985279 | 0.85 | MAPK1 (0.40) | GAAMAPTMAPK1NPC1PKM | |
| SCHEMBL49612 | 0.79 | GAA (0.52) | GAAMAPTNPC1RAB9A | |
| SCHEMBL3665728 | 0.78 | GAA (0.33) | GAAMAPTNPC1PKMRAB9A | |
| Phosphine SCHEMBL28142196 | 0.78 | GAA (0.50) | GAAMAPTNPC1RAB9A | |
| SCHEMBL2652520 | 0.77 | — | — | |
| SCHEMBL10554989 | 0.76 | GAA (0.44) | GAAMAPTNPC1PKMRAB9A | |
| SCHEMBL3635215 | 0.76 | NPC1 (0.44) | GAAMAPTMAPK1NPC1PKM | |
| SCHEMBL797826 | 0.76 | TNKS (0.40) | GAAMAPTMAPK1NPC1RAB9A | |
| SCHEMBL28279252 | 0.76 | ALDH1A1 (0.46) | GAAMAPTNPC1PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999051590-A1 | SUBSTITUTED INDOLINONES AS KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-14 | — | — | WO | claimed |
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |