Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 8/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666568 | 0.93 | PRKAA2 (0.40) | PRKAA2EPHX2MAOAMAOBPRKAB2 | |
| SCHEMBL3802167 | 0.92 | CHRM4 (0.40) | PRKAA2EPHX2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL650753 | 0.89 | PRKAA2 (0.51) | PRKAA2EPHX2MAOAMAOBPRKAB2 | |
| SCHEMBL3669184 | 0.89 | AR (0.39) | CHRM4MCHR1ARCHRM2CHRM1 | |
| SCHEMBL3665362 | 0.85 | PRKAA2 (0.40) | PRKAA2EPHX2MCHR1 | |
| SCHEMBL3667429 | 0.84 | SLC6A4 (0.40) | PRKAA2MCHR1ARUTS2R | |
| SCHEMBL3665902 | 0.83 | AR (0.41) | PRKAA2EPHX2MCHR1ARUTS2R | |
| SCHEMBL649554 | 0.82 | PRKAA2 (0.51) | PRKAA2EPHX2MAOAMAOBPRKAB2 | |
| SCHEMBL3665359 | 0.81 | UTS2R (0.45) | PRKAA2EPHX2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL10126949 | 0.81 | PRKAA2 (0.53) | PRKAA2MAOAMAOBPRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |