Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | LPL | P06858 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666339 | 0.95 | SLC6A4 (0.40) | SLC6A4DRD4F10SLC6A5HRH3 | |
| SCHEMBL3665362 | 0.93 | PRKAA2 (0.40) | SLC6A4DRD4SLC6A5MCHR1PRKAA2 | |
| SCHEMBL3662664 | 0.93 | SLC6A5 (0.46) | SLC6A4DRD4SLC6A5MCHR1 | |
| SCHEMBL3666568 | 0.91 | PRKAA2 (0.40) | SLC6A4DRD4SLC6A5ARPRKAA2 | |
| SCHEMBL3665282 | 0.90 | SLC6A4 (0.41) | SLC6A4DRD4SLC6A5LPLLIPG | |
| SCHEMBL648861 | 0.89 | DRD4 (0.50) | SLC6A4DRD4SLC6A5ADRB2MCHR1 | |
| SCHEMBL3668577 | 0.88 | SLC6A5 (0.45) | SLC6A4DRD4SLC6A5MCHR1 | |
| SCHEMBL3663620 | 0.87 | UTS2R (0.41) | DRD4F10SLC6A5UTS2R | |
| SCHEMBL3665902 | 0.86 | AR (0.41) | SLC6A4DRD4SLC6A5MCHR1AR | |
| SCHEMBL3802167 | 0.86 | CHRM4 (0.40) | MCHR1UTS2RPRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |