Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 6/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.37 |
| ▸ | CETP | P11597 | 2/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666017 | 0.93 | PRKAA2 (0.40) | PRKAA2EPHX2MAOAMAOBAR | |
| SCHEMBL3665362 | 0.92 | PRKAA2 (0.40) | PRKAA2EPHX2SLC6A4DRD4SLC6A5 | |
| SCHEMBL3667429 | 0.91 | SLC6A4 (0.40) | PRKAA2ARSLC6A4DRD4SLC6A5 | |
| SCHEMBL649554 | 0.89 | PRKAA2 (0.51) | PRKAA2EPHX2MAOAMAOBPRKAB2 | |
| SCHEMBL3665902 | 0.89 | AR (0.41) | PRKAA2EPHX2ARSLC6A4DRD4 | |
| SCHEMBL3665359 | 0.87 | UTS2R (0.45) | PRKAA2EPHX2ARPRKAB2PRKAG1 | |
| SCHEMBL3662664 | 0.86 | SLC6A5 (0.46) | SLC6A4DRD4SLC6A5 | |
| SCHEMBL3666339 | 0.86 | SLC6A4 (0.40) | PRKAA2ARSLC6A4DRD4SLC6A5 | |
| SCHEMBL3664005 | 0.85 | PRKAA2 (0.45) | PRKAA2EPHX2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL3802167 | 0.85 | CHRM4 (0.40) | PRKAA2EPHX2PRKAB2PRKAG1PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |