Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.37 |
| ▸ | LIPC | P11150 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MCHR2 | Q969V1 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3802167 | 0.93 | CHRM4 (0.40) | PRKAA2MCHR1KCNH2EPHX2MCHR2 | |
| SCHEMBL3667429 | 0.93 | SLC6A4 (0.40) | PRKAA2SLC6A4DRD4MCHR1SLC6A5 | |
| SCHEMBL3666568 | 0.92 | PRKAA2 (0.40) | PRKAA2SLC6A4DRD4SLC6A5EPHX2 | |
| SCHEMBL3662664 | 0.89 | SLC6A5 (0.46) | SLC6A4DRD4MCHR1KCNH2SLC6A5 | |
| SCHEMBL648326 | 0.89 | DRD4 (0.52) | PRKAA2DRD4MCHR1KCNH2SLC6A5 | |
| SCHEMBL3666339 | 0.88 | SLC6A4 (0.40) | PRKAA2SLC6A4DRD4MCHR1SLC6A5 | |
| SCHEMBL3665282 | 0.87 | SLC6A4 (0.41) | SLC6A4DRD4SLC6A5LIPGLIPC | |
| SCHEMBL3665902 | 0.86 | AR (0.41) | PRKAA2SLC6A4DRD4MCHR1KCNH2 | |
| SCHEMBL649466 | 0.85 | DRD4 (0.55) | SLC6A4DRD4MCHR1KCNH2SLC6A5 | |
| SCHEMBL3666017 | 0.85 | PRKAA2 (0.40) | PRKAA2MCHR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |