Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 7/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5240396 | 0.81 | HTR2C (0.50) | NISCHHTR2CHTR2BHTR2ANPC1 | |
| SCHEMBL1254610 | 0.81 | SLC6A3 (0.44) | TAAR1HTR2CHTR2BHTR2A | |
| SCHEMBL1255265 | 0.80 | HTR1A (0.55) | HTR2CHTR2BHTR2A | |
| SCHEMBL1616732 | 0.80 | KDM1A (0.38) | NOS3 | |
| SCHEMBL571789 | 0.79 | SLC18A3 (0.41) | TAAR1NISCHNFKB1 | |
| SCHEMBL4374233 | 0.77 | CHRNB2 (0.40) | HTR6HTR2CHTR2BHTR2A | |
| SCHEMBL2218295 | 0.77 | HTR2C (0.54) | NISCHHTR2CHTR2BHTR2ANPC1 | |
| SCHEMBL8658279 | 0.75 | — | — | |
| SCHEMBL3151536 | 0.75 | TAAR1 (0.47) | TAAR1NOS3HTR2CHTR2BHTR2A | |
| SCHEMBL7289047 | 0.74 | MAOA (0.40) | HTR2CSMN1; SMN2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150532-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | Evotec AG (DE) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008122787-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | EVOTEC AG (DE) | 2008-10-16 | — | — | WO | disclosed |