Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 8/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665118 | 0.88 | POLB (0.34) | TXNRD1KDM4CPOLBHTR6NPC1 | |
| SCHEMBL3666543 | 0.85 | HTR6 (0.41) | TXNRD1KDM4CNR3C1HTR6 | |
| SCHEMBL3027646 | 0.83 | KDM4C (0.39) | TXNRD1KDM4CNR3C1HTR6 | |
| SCHEMBL3027641 | 0.83 | KDM4C (0.39) | TXNRD1KDM4CNR3C1HTR6 | |
| SCHEMBL3665116 | 0.77 | TXNRD1 (0.34) | TXNRD1POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL3667381 | 0.75 | KDM4C (0.35) | KDM4CHTR6 | |
| SCHEMBL3025404 | 0.70 | KDM4C (0.40) | KDM4C | |
| SCHEMBL17378828 | 0.68 | HTR6 (0.45) | KDM4CHTR6 | |
| SCHEMBL31055976 | 0.68 | BDKRB1 (0.36) | POLBNPC1RAB9AHSF1BRD4 | |
| SCHEMBL10652127 | 0.67 | MEN1 (0.45) | TXNRD1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139898-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008128961-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |