Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 6/20 | 0.34 |
| ▸ | BRD4 | O60885 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667380 | 0.88 | MAPK8 (0.33) | SYK | |
| SCHEMBL3666540 | 0.77 | TXNRD1 (0.35) | TXNRD1BRD4POLBNPC1RAB9A | |
| SCHEMBL3027641 | 0.77 | KDM4C (0.39) | TXNRD1 | |
| SCHEMBL3666543 | 0.77 | HTR6 (0.41) | TXNRD1 | |
| SCHEMBL3027646 | 0.77 | KDM4C (0.39) | TXNRD1 | |
| SCHEMBL3665118 | 0.74 | POLB (0.34) | TXNRD1BRD4POLBNPC1RAB9A | |
| SCHEMBL7876716 | 0.67 | MAPK1 (0.48) | TXNRD1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL10652127 | 0.66 | MEN1 (0.45) | TXNRD1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL2175387 | 0.66 | TXNRD1 (0.44) | TXNRD1NPC1RAB9AMAPTMEN1 | |
| SCHEMBL10708935 | 0.66 | MAOA (0.48) | TXNRD1POLBRAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139898-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008128961-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |