Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 11/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660163 | 0.94 | F10 (0.39) | PRKAA2MDM2F10SLC6A5RAF1 | |
| SCHEMBL3664005 | 0.92 | PRKAA2 (0.45) | PRKAA2GPR6EPHX2PRKAB2PRKAG1 | |
| SCHEMBL650631 | 0.88 | PRKAA2 (0.51) | PRKAA2SLC6A5DRD4PRKAB2PRKAG1 | |
| SCHEMBL3668637 | 0.87 | PRKAA2 (0.43) | PRKAA2F10SLC6A5DRD4PRKAB2 | |
| SCHEMBL3665362 | 0.84 | PRKAA2 (0.40) | PRKAA2SLC6A5FFAR1EPHX2DRD4 | |
| SCHEMBL4441003 | 0.83 | DRD4 (0.43) | F10SLC6A5DRD4 | |
| SCHEMBL648255 | 0.82 | SLC6A5 (0.49) | PRKAA2SLC6A5DRD4 | |
| SCHEMBL3798034 | 0.82 | SLC6A5 (0.50) | PRKAA2SLC6A5FFAR1PRKAB2PRKAG1 | |
| SCHEMBL3801004 | 0.82 | PRKAA2 (0.53) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3664555 | 0.81 | MEN1 (0.40) | MDM2F10SLC6A5DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |