Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.36 |
| ▸ | LPL | P06858 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666697 | 0.94 | PRKAA2 (0.43) | F10EPHX2RAF1BRAFSLC6A5 | |
| SCHEMBL3664005 | 0.92 | PRKAA2 (0.45) | EPHX2RORCPRKAA2 | |
| SCHEMBL4441003 | 0.88 | DRD4 (0.43) | F10SLC6A5DRD4KCNH2OPRK1 | |
| SCHEMBL648255 | 0.88 | SLC6A5 (0.49) | SLC6A5DRD4PRKAA2KCNH2 | |
| SCHEMBL3664555 | 0.87 | MEN1 (0.40) | F10SLC6A5RORCMDM2DRD4 | |
| SCHEMBL3666588 | 0.87 | SSTR5 (0.42) | F10SLC6A5RORCDRD4PRKAA2 | |
| SCHEMBL3667429 | 0.86 | SLC6A4 (0.40) | F10SLC6A5DRD4PRKAA2LPL | |
| SCHEMBL3662737 | 0.85 | MDM2 (0.41) | F10SLC6A5MDM2DRD4PRKAA2 | |
| SCHEMBL3663620 | 0.85 | UTS2R (0.41) | F10SLC6A5DRD4 | |
| SCHEMBL3666339 | 0.85 | SLC6A4 (0.40) | F10SLC6A5DRD4PRKAA2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |