Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666588 | 0.91 | SSTR5 (0.42) | DRD4F10DRD2SLC6A5AR | |
| SCHEMBL4430744 | 0.90 | PRKAA2 (0.46) | F10OPRM1OPRK1KCNH2AR | |
| SCHEMBL3664555 | 0.88 | MEN1 (0.40) | DRD4F10DRD2HTR2ASLC6A5 | |
| SCHEMBL3660163 | 0.88 | F10 (0.39) | DRD4F10OPRK1KCNH2SLC6A5 | |
| SCHEMBL2388500 | 0.88 | DRD4 (0.57) | DRD4OPRK1KCNH2DRD2HTR2A | |
| SCHEMBL3667429 | 0.86 | SLC6A4 (0.40) | DRD4F10SLC6A5AR | |
| SCHEMBL3665414 | 0.86 | SLC6A5 (0.50) | DRD4OPRM1OPRK1KCNH2DRD2 | |
| SCHEMBL3661407 | 0.85 | SLC6A5 (0.42) | DRD4DRD2SLC6A5KMT2A | |
| SCHEMBL3662737 | 0.85 | MDM2 (0.41) | DRD4F10DRD2SLC6A5 | |
| SCHEMBL3663620 | 0.85 | UTS2R (0.41) | DRD4F10SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079694-A1 | N-SUBSTITUTED-HETEROCYCLOALKYLOXYBENZAMIDE COMPOUNDS AND METHODS OF USE | Rigel Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | claimed |
| WO-2008083124-A1 | N-SUBSTITUTED-HETEROCYCLOALKYLOXYBENZAMIDE COMPOUNDS AND METHODS OF USE | RIGEL PHARMACEUTICALS, INC. (US) | 2008-07-10 | — | — | WO | claimed |