SCHEMBL3666867

SCHEMBL3666867

CC(=O)N(Cc1cccc(-c2cc(C(F)(F)F)ccc2O)c1)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.56
PDK1 Q15118 1/20 0.45
LTB4R2 Q9NPC1 1/20 0.45
SERPINE1 P05121 1/20 0.44
TSPO P30536 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
PTGDR2 Q9Y5Y4 4/20 0.42
THRA P10827 1/20 0.42
THRB P10828 1/20 0.42
CETP P11597 2/20 0.40
CRHBP P24387 1/20 0.40
CRHR2 Q13324 1/20 0.40
GPBAR1 Q8TDU6 1/20 0.39
MCL1 Q07820 1/20 0.39
TACR1 P25103 1/20 0.39
PTPN5 P54829 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3666865 0.89 HDAC6 (0.56) HDAC6PDK1LTB4R2SERPINE1TSPO
SCHEMBL1948555 0.84 PTGDR2 (0.64) HDAC6PTGDR2
SCHEMBL3670884 0.83 PTGDR2 (0.44) HDAC6PDK1LTB4R2SERPINE1HDAC11
SCHEMBL3671611 0.80 PDK1 (0.54) HDAC6PDK1TACR1MEN1KMT2A
SCHEMBL3667989 0.78 HDAC6 (0.41) HDAC6HDAC11HDAC8THRATHRB
SCHEMBL3668638 0.78 MTOR (0.64) TACR1MEN1KMT2A
SCHEMBL3666876 0.78 ABHD6 (0.54) PDK1PTGDR2THRATHRBMCL1
SCHEMBL3668839 0.77 NR1H3 (0.53) HDAC6PTGDR2THRATHRBMEN1
SCHEMBL3672481 0.74 MTOR (0.43) PDK1LTB4R2THRATHRBTACR1
SCHEMBL3671902 0.74 LIPE (0.46) PDK1PTGDR2THRATHRBTACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2240434-A1 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS Ligand Pharmaceuticals Inc. (US) 2010-10-20 EP claimed
WO-2009089192-A1 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS LIGAND PHARMACEUTICALS INC. (US) 2009-07-16 WO claimed
EP-2240434-A1 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS Ligand Pharmaceuticals Inc. (US) 2010-10-20 EP disclosed
WO-2009089192-A1 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS LIGAND PHARMACEUTICALS INC. (US) 2009-07-16 WO disclosed