Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 4/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11785939 | 0.88 | CNR2 (0.49) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL21501690 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10GLA | |
| SCHEMBL5392212 | 0.82 | KDM4E (0.58) | KDM4EALDH1A1HPGDHSD17B10IDO1 | |
| SCHEMBL2493412 | 0.81 | IDO1 (0.50) | KDM4EALDH1A1HPGDHSD17B10IDO1 | |
| SCHEMBL17234479 | 0.78 | ALDH1A1 (0.71) | KDM4EALDH1A1HPGDHSD17B10GLA | |
| SCHEMBL963365 | 0.77 | L3MBTL1 (0.49) | KDM4EALDH1A1HPGDHSD17B10IDO1 | |
| SCHEMBL14470975 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10IDO1 | |
| SCHEMBL1902821 | 0.76 | HPGD (0.69) | KDM4EALDH1A1HPGDHSD17B10GLA | |
| SCHEMBL28454558 | 0.76 | ADRA1A (0.53) | KDM4EALDH1A1HPGDHSD17B10IDO1 | |
| SCHEMBL11512622 | 0.76 | IDO1 (0.55) | KDM4EIDO1GLAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170846-A2 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | Intervet International BV (NL) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009005646-A2 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
| US-7459442-B2 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof | SCHERING CORPORATION (US) | 2008-12-02 | — | — | US | disclosed |
| WO-2007123949-A2 | CANNABINOID RECEPTOR MODULATORS | SCHERING CORPORATION (US) | 2007-11-01 | — | — | WO | disclosed |
| EP-1819684-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006060461-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2006-06-08 | — | — | WO | disclosed |