Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.61 |
| ▸ | APP | P05067 | 3/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 10/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 10/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | FABP2 | P12104 | 1/20 | 0.56 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14892302 | 0.85 | APP (0.54) | PTGS2CYP2C19APPAKR1C3AKR1C2 | |
| SCHEMBL5122373 | 0.84 | ACHE (0.61) | PTGS2CYP2C19AKR1C3AKR1C2PTGS1 | |
| SCHEMBL490776 | 0.84 | ACHE (0.61) | PTGS2CYP2C19AKR1C3AKR1C2PTGS1 | |
| SCHEMBL14032691 | 0.84 | ACHE (0.61) | PTGS2CYP2C19AKR1C3AKR1C2PTGS1 | |
| SCHEMBL30536168 | 0.83 | BLM (0.64) | PTGS2CYP2C19APPAKR1C3AKR1C2 | |
| SCHEMBL3621168 | 0.83 | LMNA (0.56) | PTGS2CYP2C19APPAKR1C3AKR1C2 | |
| SCHEMBL8320075 | 0.83 | APP (0.72) | PTGS2CYP2C19APPAKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL3225395 | 0.83 | ACHE (0.59) | PTGS2CYP2C19AKR1C3AKR1C2PTGS1 | |
| SCHEMBL3817028 | 0.82 | LMNA (0.54) | PTGS2CYP2C19APPMEN1KMT2A | |
| SCHEMBL490724 | 0.81 | AKR1C3 (0.57) | PTGS2CYP2C19APPAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-20060276476-A1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | BIEDIGER RONALD J | 2006-12-07 | — | — | US | disclosed |
| US-6972296-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-12-06 | — | — | US | disclosed |
| US-4310675-A | Monoradioiodinated imidazole derivatives | BECTON DICKINSON & COMPANY (US) | 1982-01-12 | — | — | US | disclosed |
| US-4202874-A | Monoradioiodinated derivatives and precursors for production thereon | BECTON DICKINSON & COMPANY (US) | 1980-05-13 | — | — | US | disclosed |
| US-4120867-A | Monoradioiodinated phenolic esters, acids and amines | BECTON, DICKINSON & COMPANY (US) | 1978-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276476-A1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | VCAM1, ICAM1, ITGA1 | PTGS2 3523/4885CYP2C19 2494/4885APP 2269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.