Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 11/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 11/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 11/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3662664 | 0.95 | SLC6A5 (0.46) | SLC6A5CHRNB2CHRNA7CHRNA4SLC6A4 | |
| SCHEMBL3666339 | 0.93 | SLC6A4 (0.40) | SLC6A5CHRNB2CHRNA7CHRNA4SLC6A4 | |
| SCHEMBL646987 | 0.89 | SLC6A5 (0.57) | SLC6A5CHRNB2CHRNA7CHRNA4SLC6A4 | |
| SCHEMBL647529 | 0.88 | SLC6A5 (0.52) | SLC6A5CHRNB2CHRNA7CHRNA4SLC6A4 | |
| SCHEMBL647530 | 0.88 | SLC6A5 (0.52) | SLC6A5CHRNB2CHRNA7CHRNA4SLC6A4 | |
| SCHEMBL3667429 | 0.88 | SLC6A4 (0.40) | SLC6A5SLC6A4MCHR1DRD4 | |
| SCHEMBL3798034 | 0.85 | SLC6A5 (0.50) | SLC6A5KCNH2MCHR1FFAR1HIF1A | |
| SCHEMBL3665414 | 0.85 | SLC6A5 (0.50) | SLC6A5KCNH2MCHR1DRD4FFAR1 | |
| SCHEMBL648168 | 0.85 | SLC6A5 (0.58) | SLC6A5SLC6A4KCNH2MCHR1DRD4 | |
| SCHEMBL3665362 | 0.84 | PRKAA2 (0.40) | SLC6A5SLC6A4KCNH2MCHR1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |