Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365914 | 0.93 | MAPT (0.34) | PLA2G4AS1PR3MAPTTP53LMNA | |
| SCHEMBL365188 | 0.91 | CYP11B1 (0.39) | LMNAACHECYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL366850 | 0.90 | MAPT (0.37) | PLA2G4AMAPTTP53LMNAPABPC1 | |
| SCHEMBL366611 | 0.84 | ACHE (0.38) | MAPTACHEPABPC1CYP11B1CYP11B2 | |
| SCHEMBL366750 | 0.84 | PPARG (0.33) | MAPTPABPC1CYP11B1CYP11B2CNR2 | |
| SCHEMBL365168 | 0.83 | ACHE (0.41) | ACHE | |
| SCHEMBL366373 | 0.82 | MAPT (0.37) | PLA2G4AMAPTTP53LMNAACHE | |
| SCHEMBL365768 | 0.81 | ALOX5 (0.38) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL365005 | 0.80 | CYP11B1 (0.37) | MAPTACHECYP11B1CYP11B2KDM4E | |
| SCHEMBL366900 | 0.80 | S1PR3 (0.39) | PLA2G4AS1PR3NPC1RAB9AGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |