Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | BDKRB2 known ✓ | P30411 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.31 |
| ▸ | HTR1A | P08908 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5671803 | 0.96 | ALDH1A1 (0.39) | ALDH1A1GABRA1GABRB2ADRA2CADRB2 | |
| SCHEMBL30641415 | 0.82 | GABRA1 (0.47) | ALDH1A1GABRA1GABRB2ADRA2CADRB2 | |
| SCHEMBL535990 | 0.82 | GABRA1 (0.47) | ALDH1A1GABRA1GABRB2ADRA2CADRB2 | |
| SCHEMBL6025866 | 0.80 | ALDH1A1 (0.39) | ALDH1A1GABRA1GABRB2ADRA2CADRB2 | |
| SCHEMBL6289164 | 0.78 | ALDH1A1 (0.38) | ALDH1A1GABRA1GABRB2ADRA2CADRB2 | |
| SCHEMBL810093 | 0.78 | ALDH1A1 (0.42) | ALDH1A1GABRA1GABRB2ADRA2CADRB2 | |
| SCHEMBL28579563 | 0.78 | SLC6A2 (0.45) | ALDH1A1ADRB1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL3669290 | 0.78 | ALDH1A1 (0.38) | ALDH1A1GABRA1GABRB2ADRA2CADRB2 | |
| SCHEMBL5033204 | 0.77 | ALDH1A1 (0.36) | ALDH1A1GABRA1GABRB2ADRA2CADRB2 | |
| Hydrochloric Acid SCHEMBL10485992 | 0.77 | HIF1A (0.40) | ALDH1A1TSHRCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0561033-B1 | Polymeric phoshonium salts providing enhanced chemiluminescence from 1,2-dioxetanes, and their use. | LUMIGEN INC (US) | 2000-03-15 | — | — | EP | claimed |
| US-5393469-A | Triggering dioxetane with activating agents consisting of acids, bases, salts, enzymes, inorganic or organic catalysts and electron donors; used for immunoassay and nucleic acid assay | LUMIGEN, INC. (US) | 1995-02-28 | — | — | US | claimed |
| EP-0561033-A1 | Polymeric phoshonium salts providng enhanced chemiluminescence from 1,2-dioxetanes | LUMIGEN, INC. (US) | 1993-09-22 | — | — | EP | claimed |
| EP-2240415-A1 | COMPOSITE POLYMERIC FILTRATION MEDIA | 3M Innovative Properties Company (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009102386-A1 | COMPOSITE POLYMERIC FILTRATION MEDIA | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2009-08-20 | — | — | WO | disclosed |
| EP-0561033-B1 | Polymeric phoshonium salts providing enhanced chemiluminescence from 1,2-dioxetanes, and their use. | LUMIGEN INC (US) | 2000-03-15 | — | — | EP | disclosed |
| US-5582775-A | WATER SOLUBLE; PREPARED BY REACTING AT LEAST TWO DIFFERENT PHOSPHINES WITH POLYVINYL POLYMER | LUMIGEN, INC. (US) | 1996-12-10 | — | — | US | disclosed |
| US-5474725-A | Reacting polyvinylbenzyl chloride with a trialkylphosphine to form salt | LUMIGEN, INC. (US) | 1995-12-12 | — | — | US | disclosed |
| US-5439617-A | Composition containing stable 1,2-dioxetane, polyvinyl phosphonium salt polymer | LUMIGEN, INC. (US) | 1995-08-08 | — | — | US | disclosed |
| US-5431845-A | Polymeric phosphonium salts providing enhanced chemiluminescence from 1,2-dioxetanes | LUMIGEN, INC. (US) | 1995-07-11 | — | — | US | disclosed |
| US-5393469-A | Triggering dioxetane with activating agents consisting of acids, bases, salts, enzymes, inorganic or organic catalysts and electron donors; used for immunoassay and nucleic acid assay | LUMIGEN, INC. (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0561033-A1 | Polymeric phoshonium salts providng enhanced chemiluminescence from 1,2-dioxetanes | LUMIGEN, INC. (US) | 1993-09-22 | — | — | EP | disclosed |