Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 4/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551898 | 0.83 | MAPT (0.31) | MAPT | |
| SCHEMBL8548071 | 0.77 | L3MBTL1 (0.34) | KDM4EHSD17B10MAPTVCAM1HPGD | |
| SCHEMBL2903425 | 0.74 | LMNA (0.32) | MAPTSMN1; SMN2LMNA | |
| SCHEMBL3686484 | 0.74 | RXFP1 (0.54) | RXFP1KDM4EHSD17B10POLBMCOLN3 | |
| SCHEMBL3668017 | 0.73 | CCR6 (0.36) | KDM4EHSD17B10POLBCASP3MAPT | |
| SCHEMBL3674251 | 0.71 | TSHR (0.38) | KDM4EHSD17B10POLBCASP3TSHR | |
| SCHEMBL3668151 | 0.68 | GPR35 (0.42) | KDM4EHSD17B10POLBCASP3MAOA | |
| SCHEMBL8608349 | 0.68 | KMT2A (0.39) | POLBMAPTTSHRMEN1KMT2A | |
| SCHEMBL9036583 | 0.65 | CA2 (0.45) | KDM4EPOLBMAPTVCAM1HPGD | |
| SCHEMBL3686813 | 0.63 | KDM4E (0.48) | RXFP1KDM4EHSD17B10POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150248-A2 | GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE | The Johns Hopkins University (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008088820-A2 | GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-07-24 | — | — | WO | disclosed |