Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 9/20 | 0.48 |
| ▸ | PTGIR | P43119 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3169026 | 0.87 | ADRA2A (0.55) | PTGIRADRA2BADRA2CADRA2AADRA1A | |
| SCHEMBL3169468 | 0.79 | PTGIR (0.60) | WDR5PTGIRADRA2BADRA2CADRA2A | |
| SCHEMBL27797575 | 0.79 | WDR5 (0.45) | WDR5PTGIRADRA2BADRA2CADRA2A | |
| SCHEMBL8148008 | 0.77 | LMNA (0.52) | WDR5PTGIRADRA2BADRA2CADRA2A | |
| SCHEMBL11591507 | 0.76 | ADRA2A (0.57) | PTGIRADRA2BADRA2CADRA2AADRA1A | |
| SCHEMBL29412295 | 0.75 | ADRA2A (0.65) | ADRA2BADRA2CADRA2AADRA1AHTR7 | |
| Hydrochloric Acid SCHEMBL11513827 | 0.75 | ADRA2A (0.58) | PTGIRADRA2BADRA2CADRA2AADRA1A | |
| SCHEMBL11198769 | 0.74 | ADRA2A (0.58) | PTGIRADRA2BADRA2CADRA2AADRA1A | |
| SCHEMBL11203702 | 0.74 | ADRA2A (0.60) | ADRA2BADRA2CADRA2AADRA1AHTR7 | |
| SCHEMBL10965126 | 0.72 | ADRA2C (0.74) | ADRA2BADRA2CADRA2AADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173720-A2 | 2-IMIDAZOLINES HAVING A GOOD AFFINITY TO THE TRACE AMINE ASSOCIATED RECEPTORS (TAARS) | F. Hoffmann-Roche AG (CH) | 2010-04-14 | — | — | EP | claimed |
| WO-2009003868-A2 | 2 -IMIDAZOLINES HAVING A GOOD AFFINITY TO THE TRACE AMINE ASSOCIATED RECEPTORS (TAARS) | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-08 | — | — | WO | claimed |