SCHEMBL3670516

SCHEMBL3670516

O=C1[N]c2cc([N+](=O)[O-])c(C(F)(F)F)cc2NC1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.40
CA9 Q16790 1/20 0.40
AR P10275 5/20 0.38
CYP3A4 P08684 4/20 0.38
TSHR P16473 3/20 0.38
LMNA P02545 2/20 0.38
CYP1A2 P05177 2/20 0.38
PGR P06401 2/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
MEN1 O00255 1/20 0.38
TP53 P04637 1/20 0.38
CYP2D6 P10635 1/20 0.38
ALOX12 P18054 1/20 0.38
NFKB1 P19838 1/20 0.38
RAB9A P51151 1/20 0.38
KMT2A Q03164 1/20 0.38
PDE4D Q08499 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8128055 0.84 CYP3A4 (0.39) CYP3A4TSHRLMNACYP1A2CYP2C9
SCHEMBL8128825 0.82 CES1 (0.31) CYP3A4
SCHEMBL8118374 0.81 ESPL1 (0.38) CYP3A4TSHRLMNACYP1A2PGR
SCHEMBL8555748 0.78 ALDH1A1 (0.40) CYP3A4TSHRLMNACYP1A2MEN1
SCHEMBL8115079 0.78 ESPL1 (0.38) CYP3A4TSHRLMNACYP1A2PGR
SCHEMBL8559761 0.78 AKR1B1 (0.40) CA12CA9CYP3A4TSHRLMNA
SCHEMBL8554501 0.77 HTR2C (0.37) ARCYP1A2MEN1NFKB1KMT2A
SCHEMBL3672889 0.75 MAPT (0.37) CYP3A4TSHRLMNACYP1A2CYP2C9
SCHEMBL3675510 0.75 ABCC8 (0.34) ARCYP3A4TSHRLMNACYP1A2
SCHEMBL8121012 0.73 ABCC8 (0.33) ARCYP3A4TSHRLMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0647137-A4 GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF. UNIV CALIFORNIA WEBER ECKARD (US) 1998-09-16 EP claimed
EP-0647137-A1 GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-04-12 EP claimed
EP-2150248-A2 GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE The Johns Hopkins University (US) 2010-02-10 EP disclosed
WO-2008088820-A2 GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE THE JOHNS HOPKINS UNIVERSITY (US) 2008-07-24 WO disclosed
EP-0696288-B1 QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS SCHERING AG (DE) 2000-09-20 EP disclosed
EP-0647137-A4 GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF. UNIV CALIFORNIA WEBER ECKARD (US) 1998-09-16 EP disclosed
EP-0647137-A1 GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-04-12 EP disclosed