Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365499 | 0.93 | P4HTM (0.38) | LMNAADAM17MAPTPTGER4POLB | |
| SCHEMBL366344 | 0.88 | PSEN1 (0.39) | LMNAADAM17SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL364821 | 0.87 | ADAM17 (0.41) | LMNAADAM17SMN1; SMN2HTTMAPT | |
| SCHEMBL367073 | 0.87 | ALDH1A1 (0.45) | LMNAADAM17SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL365603 | 0.85 | TSHR (0.38) | LMNAADAM17SMN1; SMN2HTTMAPT | |
| SCHEMBL364894 | 0.85 | PSEN1 (0.39) | LMNAADAM17HTTMAPTPTGER4 | |
| SCHEMBL364828 | 0.85 | MCL1 (0.37) | ADAM17MCL1PSEN1PSEN2APH1B | |
| SCHEMBL367542 | 0.83 | PSEN1 (0.42) | ADAM17POLBALDH1A1MCL1PSEN1 | |
| SCHEMBL364734 | 0.81 | LMNA (0.40) | LMNASMN1; SMN2L3MBTL1HTTTDP1 | |
| SCHEMBL366980 | 0.81 | PTGER4 (0.41) | PTGER4MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |