Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31543456 | 0.86 | KDM1A (0.37) | KDM1AMAOAMAOBPARP1MBOAT4 | |
| SCHEMBL17441533 | 0.82 | NOS3 (0.40) | KDM1AMAOAMAOBPARP1MBOAT4 | |
| SCHEMBL14279059 | 0.78 | GABRA1 (0.38) | KDM1AMAOAMAOBPARP1MBOAT4 | |
| SCHEMBL30401571 | 0.74 | NOS2 (0.41) | KDM1AMAOAMAOBPARP1MBOAT4 | |
| SCHEMBL1249740 | 0.74 | NOS2 (0.41) | KDM1AMAOAMAOBPARP1MBOAT4 | |
| SCHEMBL101950 | 0.74 | — | — | |
| SCHEMBL8739934 | 0.73 | PARP1 (0.46) | KDM1AMAOAMAOBPARP1MBOAT4 | |
| SCHEMBL31546726 | 0.73 | KDM1A (0.38) | KDM1AMAOAMAOBPARP1MBOAT4 | |
| SCHEMBL2071082 | 0.73 | LTB4R (0.39) | KDM1AMAOAMAOBMBOAT4FAAH | |
| SCHEMBL25306585 | 0.72 | MAOA (0.34) | KDM1AMAOAMAOBPARP1MBOAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |