Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.35 |
| ▸ | USP2 | O75604 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7102528 | 0.90 | FDPS (0.49) | FDPSLTA4HHDAC1HDAC6CYP1A2 | |
| SCHEMBL10857669 | 0.85 | FDPS (0.54) | FDPSLTA4HHDAC1HDAC6CYP1A2 | |
| SCHEMBL27932506 | 0.84 | FDPS (0.53) | FDPSLTA4HHDAC1HDAC6CYP1A2 | |
| SCHEMBL9597540 | 0.82 | FDPS (0.55) | FDPSLTA4HHDAC1HDAC6CYP1A2 | |
| SCHEMBL31024294 | 0.82 | FDPS (0.51) | FDPSLTA4HHDAC1HDAC6CYP1A2 | |
| SCHEMBL28231111 | 0.82 | FDPS (0.51) | FDPSLTA4HHDAC1HDAC6CYP1A2 | |
| SCHEMBL10163117 | 0.82 | FDPS (0.51) | FDPSLTA4HHDAC1HDAC6CYP1A2 | |
| SCHEMBL4020843 | 0.82 | FDPS (0.51) | FDPSLTA4HHDAC1HDAC6CYP1A2 | |
| SCHEMBL5017277 | 0.82 | FDPS (0.51) | FDPSLTA4HHDAC1HDAC6CYP1A2 | |
| SCHEMBL6259635 | 0.82 | FDPS (0.55) | FDPSLTA4HHDAC1HDAC6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831812-B1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH | VERTEX PHARMA (US) | 2005-12-07 | — | — | EP | claimed |
| EP-0584223-B1 | NOVEL IMMUNOSUPPRESSIVE COMPOUNDS | VERTEX PHARMA (US) | 1999-08-11 | — | — | EP | claimed |
| US-5620971-A | Biologically active acylated amino acid derivatives | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1997-04-15 | — | — | US | claimed |
| EP-0584223-A1 | NOVEL IMMUNOSUPPRESSIVE COMPOUNDS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1994-03-02 | — | — | EP | claimed |
| WO-1992019593-A1 | NOVEL IMMUNOSUPPRESSIVE COMPOUNDS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1992-11-12 | — | — | WO | claimed |
| US-7825136-B2 | Potentiators of antibacterial activity | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-02 | — | — | US | disclosed |
| US-20090291964-A1 | Potentiators of Antibacterial Activity | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-26 | — | — | US | disclosed |
| CN-1234718-C | New macrolides with antibacterial activity | BASILEA PHARMACEUTICA AG (CH) | 2006-01-04 | — | — | CN | disclosed |
| US-20050090482-A1 | mixture of antibiotics, carriers and activators such as (S)-1-((3,4,5-Trimethoxyphenyl)-methyl-carbamoyl)-piperidine-2-carboxylic acid 4-pyridin-3-yl-1-(3-pyridin-3-yl-propyl)-butyl ester, used for treatment of bacterial infection in mammals | VERTEX PHARMACEUTICALS INCORPORATED | 2005-04-28 | — | — | US | disclosed |
| CN-1464880-A | New macrolides with antibacterial activity | BASILEA PHARMACEUTICA AG (CH) | 2003-12-31 | — | — | CN | disclosed |
| US-6326387-B1 | NEUROTROPIC COMPOUND | VERTEX PHARMACEUTICALS INCORPORATED | 2001-12-04 | — | — | US | disclosed |
| EP-1117372-A2 | METHOD OF TREATING HAIR LOSS USING SULFONAMIDES | THE PROCTER & GAMBLE COMPANY (US) | 2001-07-25 | — | — | EP | disclosed |
| EP-1117371-A2 | METHOD OF TREATING HAIR LOSS USING KETOAMIDES | The Procter & Gamble Company (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018358-A2 | METHOD OF TREATING HAIR LOSS USING KETOAMIDES | THE PROCTER & GAMBLE COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |
| WO-2000018361-A2 | METHOD OF TREATING HAIR LOSS USING SULFONAMIDES | THE PROCTER & GAMBLE COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291964-A1 | Potentiators of Antibacterial Activity | SLC11A2, MPO, ABCB11 | FDPS 61/4885LTA4H 1214/4885HDAC1 1520/4885 |
| US-20050090482-A1 | mixture of antibiotics, carriers and activators such as (S)-1-((3,4,5-Trimethoxyphenyl)-methyl-carbamoyl)-piperidine-2-carboxylic acid 4-pyridin-3-yl-1-(3-pyridin-3-yl-propyl)-butyl ester, used for treatment of bacterial infection in mammals | TLR1, ABCB11, SLC7A1 | FDPS 346/4885LTA4H 1084/4885HDAC1 468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.