Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3668626 | 0.82 | NISCH (0.35) | MEN1TSHRKMT2ANISCH | |
| Hydrochloric Acid SCHEMBL346593 | 0.82 | ADRA2A (0.34) | RAB9ASMN1; SMN2NISCH | |
| Hydrochloric Acid SCHEMBL8762954 | 0.80 | CA4 (0.30) | — | |
| Hydrochloric Acid SCHEMBL15122062 | 0.75 | BACE1 (0.36) | RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL618964 | 0.70 | KDM4E (0.31) | SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5729183 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL7931040 | 0.68 | TSHR (0.40) | MEN1NPC1TSHRRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL3615425 | 0.68 | MEN1 (0.33) | MEN1NPC1TSHRRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL3615426 | 0.65 | MEN1 (0.33) | MEN1NPC1TSHRRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL5898891 | 0.62 | CTSD (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225251-B1 | TRANSITION METAL COMPLEXES, CATALYSTS COMPOSITION CONTAINING THE SAME, AND PROCESS FOR PREPARING ETHYLENE HOMOPOLYMERS OR COPOLYMERS OF ETHYLENE AND ALPHA-OLEFINS USING THE SAME | SABIC SK NEXLENE COMPANY PTE LTD (SG) | 2015-12-23 | — | — | EP | disclosed |
| US-8344081-B2 | Transition metal complexes, catalysts composition containing the same, and process for preparing ethylene homopolymers or copolymers of ethylene and alpha-olefins using the same | SK INNOVATION CO., LTD. (KR) | 2013-01-01 | — | — | US | disclosed |
| US-20100298512-A1 | TRANSITION METAL COMPLEXES, CATALYSTS COMPOSITION CONTAINING THE SAME, AND PROCESS FOR PREPARING ETHYLENE HOMOPOLYMERS OR COPOLYMERS OF ETHYLENE AND ALPHA-OLEFINS USING THE SAME | SK ENERGY CO., LTD. (KR) | 2010-11-25 | — | — | US | disclosed |
| EP-2225251-A1 | TRANSITION METAL COMPLEXES, CATALYSTS COMPOSITION CONTAINING THE SAME, AND PROCESS FOR PREPARING ETHYLENE HOMOPOLYMERS OR COPOLYMERS OF ETHYLENE AND ALPHA-OLEFINS USING THE SAME | SK Energy Co., Ltd. (KR) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009084805-A1 | TRANSITION METAL COMPLEXES, CATALYSTS COMPOSITION CONTAINING THE SAME, AND PROCESS FOR PREPARING ETHYLENE HOMOPOLYMERS OR COPOLYMERS OF ETHYLENE AND ALPHA-OLEFINS USING THE SAME | SK ENERGY CO., LTD. (KR) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298512-A1 | TRANSITION METAL COMPLEXES, CATALYSTS COMPOSITION CONTAINING THE SAME, AND PROCESS FOR PREPARING ETHYLENE HOMOPOLYMERS OR COPOLYMERS OF ETHYLENE AND ALPHA-OLEFINS USING THE SAME | MCM4, ESR1, SEM1 | MEN1 478/4885NPC1 1554/4885TSHR 4776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.