Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3801432 | 0.79 | SIGMAR1 (0.46) | CA1CA2CA4CA9CHRNB2 | |
| SCHEMBL5313826 | 0.75 | HPGD (0.41) | HPGDCA1CA2CA4CA9 | |
| SCHEMBL3663206 | 0.72 | DPP4 (0.43) | DPP4LMNAGAAL3MBTL1DPP7 | |
| SCHEMBL7300300 | 0.70 | FKBP1A (0.48) | — | |
| SCHEMBL9263281 | 0.70 | FKBP1A (0.48) | — | |
| SCHEMBL5148256 | 0.70 | NOTUM (0.42) | LMNAHPGDCNR2 | |
| SCHEMBL11590269 | 0.70 | SIGMAR1 (0.53) | CA1CA2CA4CA9CHRNB2 | |
| SCHEMBL3666620 | 0.69 | SMN1; SMN2 (0.42) | HPGDSLC6A2SLC6A3CHRNB2CHRNB4 | |
| SCHEMBL3671778 | 0.69 | NPSR1 (0.43) | SLC6A2SLC6A3SIGMAR1SLC6A4 | |
| SCHEMBL8498078 | 0.69 | SIGMAR1 (0.44) | CA1CA2CA4CA9CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150532-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | Evotec AG (DE) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008122787-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | EVOTEC AG (DE) | 2008-10-16 | — | — | WO | disclosed |