Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | PRNP | P04156 | 3/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29457163 | 0.84 | CYP1A2 (0.47) | KDM4EALDH1A1PRNPRXFP1NPSR1 | |
| SCHEMBL27742507 | 0.83 | ALDH1A1 (0.41) | KDM4EALDH1A1PRNPRXFP1NPSR1 | |
| SCHEMBL7136011 | 0.82 | ALDH1A1 (0.49) | KDM4EALDH1A1PRNPRXFP1NPSR1 | |
| SCHEMBL30838558 | 0.80 | ALDH1A1 (0.51) | KDM4EALDH1A1PRNPRXFP1NPSR1 | |
| SCHEMBL7774729 | 0.80 | MGAM (0.52) | KDM4EALDH1A1PRNPRXFP1NPSR1 | |
| SCHEMBL27325063 | 0.79 | MGAM (0.50) | KDM4EALDH1A1PRNPRXFP1NPSR1 | |
| SCHEMBL27721065 | 0.79 | MGAM (0.50) | KDM4EALDH1A1PRNPRXFP1NPSR1 | |
| SCHEMBL1613317 | 0.79 | MGAM (0.50) | KDM4EALDH1A1PRNPRXFP1NPSR1 | |
| SCHEMBL27519044 | 0.79 | KDM4E (0.51) | KDM4EALDH1A1PRNPRXFP1NPSR1 | |
| SCHEMBL2310345 | 0.78 | ALDH1A1 (0.48) | KDM4EALDH1A1PRNPRXFP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113248421-B | Preparation method of nifedipine | 合肥立方制药股份有限公司 | 2022-03-08 | — | — | CN | claimed |
| CN-113248421-A | Preparation method of nifedipine | 合肥立方制药股份有限公司 | 2021-08-13 | — | — | CN | claimed |
| CN-111253304-A | Preparation method of nifedipine | 合肥立方制药股份有限公司 | 2020-06-09 | — | — | CN | claimed |
| US-20230107256-A1 | QUINOLINE DERIVED SMALL MOLECULE INHIBITORS OF NICOTINAMIDE N-METHYLTRANSFERASE (NNMT) AND USES THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2023-04-06 | — | — | US | disclosed |
| CN-111517902-B | Aerobic oxidation system containing sulfinic acid, sulfonic acid or derivatives thereof and photo-oxidation promoting method thereof | 清华大学 | 2022-06-14 | — | — | CN | disclosed |
| CN-113234009-B | Preparation method of nifedipine | 合肥立方制药股份有限公司 | 2022-03-08 | — | — | CN | disclosed |
| CN-113248421-B | Preparation method of nifedipine | 合肥立方制药股份有限公司 | 2022-03-08 | — | — | CN | disclosed |
| CN-113248421-A | Preparation method of nifedipine | 合肥立方制药股份有限公司 | 2021-08-13 | — | — | CN | disclosed |
| CN-113234009-A | Preparation method of nifedipine | 合肥立方制药股份有限公司 | 2021-08-10 | — | — | CN | disclosed |
| CN-111253304-B | Preparation method of nifedipine | 合肥立方制药股份有限公司 | 2021-07-06 | — | — | CN | disclosed |
| WO-2020155595-A1 | AEROBIC OXIDATION SYSTEM CONTAINING SULFINIC ACID, SULFONIC ACID OR DERIVATIVES THEREOF AND PHOTOCATALYTIC OXIDATION METHOD THEREFOR | 清华大学 | 2020-08-06 | — | — | WO | disclosed |
| CN-111253304-A | Preparation method of nifedipine | 合肥立方制药股份有限公司 | 2020-06-09 | — | — | CN | disclosed |
| US-20200102274-A1 | QUINOLINE DERIVED SMALL MOLECULE INHIBITORS OF NICOTINAMIDE N-METHYLTRANSFERASE (NNMT) AND USES THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2020-04-02 | — | — | US | disclosed |
| EP-3600317-A1 | QUINOLINE DERIVED SMALL MOLECULE INHIBITORS OF NICOTINAMIDE N-METHYLTRANSFERASE (NNMT) AND USES THEREOF | The Board of Regents of The University of Texas System (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183668-A1 | QUINOLINE DERIVED SMALL MOLECULE INHIBITORS OF NICOTINAMIDE N-METHYLTRANSFERASE (NNMT) AND USES THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-10-04 | — | — | WO | disclosed |
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-20060276476-A1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | BIEDIGER RONALD J | 2006-12-07 | — | — | US | disclosed |
| US-6972296-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-12-06 | — | — | US | disclosed |
| EP-1196436-A2 | PEPTIDE BORONIC ACID INHIBITORS OF HEPATITIS C VIRUS PROTEASE | Bristol-Myers Squibb Pharma Company (US) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001002424-A2 | PEPTIDE BORONIC ACID INHIBITORS OF HEPATITIS C VIRUS PROTEASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276476-A1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | VCAM1, ICAM1, ITGA1 | KDM4E 2631/4885ALDH1A1 53/4885PRNP 2530/4885 |
| US-20200102274-A1 | QUINOLINE DERIVED SMALL MOLECULE INHIBITORS OF NICOTINAMIDE N-METHYLTRANSFERASE (NNMT) AND USES THEREOF | NNMT, NAMPT, NNT | KDM4E 1338/4885ALDH1A1 459/4885PRNP 3471/4885 |
| US-20230107256-A1 | QUINOLINE DERIVED SMALL MOLECULE INHIBITORS OF NICOTINAMIDE N-METHYLTRANSFERASE (NNMT) AND USES THEREOF | NNMT, NAMPT, NNT | KDM4E 1248/4885ALDH1A1 755/4885PRNP 3146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.