Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 4/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 3/20 | 0.36 |
| ▸ | CCR9 | P51686 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2811565 | 0.88 | NR1H2 (0.43) | HSD11B1L3MBTL1MTNR1AMTNR1BCCR9 | |
| SCHEMBL3675346 | 0.80 | NOD2 (0.43) | HSD11B1L3MBTL1PTGS2KDM4EALDH1A1 | |
| SCHEMBL3316267 | 0.78 | STS (0.49) | HSD11B1L3MBTL1CXCR2KDM4EALDH1A1 | |
| SCHEMBL3637923 | 0.77 | CA12 (0.44) | L3MBTL1MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL2113911 | 0.76 | STS (0.47) | HSD11B1L3MBTL1CXCR2KDM4EALDH1A1 | |
| SCHEMBL1960026 | 0.75 | LCK (0.47) | HSD11B1L3MBTL1CXCR2KDM4EALDH1A1 | |
| SCHEMBL29977263 | 0.74 | L3MBTL1 (0.45) | HSD11B1L3MBTL1CXCR2DRD2DRD3 | |
| SCHEMBL18763951 | 0.73 | HSD11B1 (0.50) | HSD11B1CXCR2PTGS2SMN1; SMN2CA1 | |
| SCHEMBL16513114 | 0.73 | HSD11B1 (0.50) | HSD11B1L3MBTL1CXCR2PTGS2DRD2 | |
| SCHEMBL15912453 | 0.73 | PLAU (0.52) | HSD11B1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170072-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008157270-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |