Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL713624 | 0.89 | ALDH1A1 (0.70) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| SCHEMBL29393238 | 0.89 | ALDH1A1 (0.70) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| SCHEMBL248317 | 0.89 | ALDH1A1 (0.70) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| SCHEMBL7030042 | 0.87 | ALDH1A1 (0.67) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| SCHEMBL16585286 | 0.87 | ALDH1A1 (0.67) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| Phthalic Acid SCHEMBL33470 | 0.87 | ALDH1A1 (0.74) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| Phthalic Acid SCHEMBL33468 | 0.87 | ALDH1A1 (0.74) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| SCHEMBL6765311 | 0.85 | ALDH1A1 (0.64) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| SCHEMBL3229052 | 0.85 | ALDH1A1 (0.64) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 | |
| Phthalic Acid SCHEMBL14920338 | 0.85 | ALDH1A1 (0.70) | ALDH1A1ALOX15KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217660-A1 | RADICALLY CROSS-LINKABLE POLYMER COMPOSITIONS CONTAINING EPOXY-FUNCTIONAL COPOLYMERS | Wacker Chemie AG (DE) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009071508-A1 | RADICALLY CROSS-LINKABLE POLYMER COMPOSITIONS CONTAINING EPOXY-FUNCTIONAL COPOLYMERS | WACKER CHEMIE AG (DE) | 2009-06-11 | — | — | WO | disclosed |