Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.65 |
| ▸ | JUN | P05412 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HBB | P68871 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3675503 | 1.00 | TRPA1 (0.65) | TRPA1JUNNFKB1KDM1AALOX5 | |
| SCHEMBL9004094 | 0.81 | TRPA1 (0.69) | TRPA1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL3675519 | 0.80 | RAB9A (0.54) | TRPA1JUNNFKB1ALOX5NPC1 | |
| SCHEMBL3675517 | 0.80 | RAB9A (0.54) | TRPA1JUNNFKB1ALOX5NPC1 | |
| SCHEMBL4457739 | 0.79 | TRPA1 (1.00) | TRPA1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1499367 | 0.79 | TRPA1 (1.00) | TRPA1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL4451132 | 0.79 | TRPA1 (1.00) | TRPA1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL9004135 | 0.79 | TRPA1 (0.70) | TRPA1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1499368 | 0.79 | TRPA1 (1.00) | TRPA1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL9004104 | 0.76 | TRPA1 (0.66) | TRPA1SMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150065538-A1 | TRPA1 ANTAGONISTS | ABBVIE INC (US) | 2015-03-05 | — | — | US | claimed |
| US-8877784-B2 | TRPA1 antagonists | ABBVIE INC. (US) | 2014-11-04 | — | — | US | claimed |
| EP-2240450-A1 | TRPA1 ANTAGONISTS | Abbott Laboratories (US) | 2010-10-20 | — | — | EP | claimed |
| US-20090264480-A1 | TRPA1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-10-22 | — | — | US | claimed |
| WO-2009089083-A1 | TRPA1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-07-16 | — | — | WO | claimed |
| US-9751850-B2 | TRPA1 antagonists | ABBVIE INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-20150065538-A1 | TRPA1 ANTAGONISTS | ABBVIE INC (US) | 2015-03-05 | — | — | US | disclosed |
| US-8877784-B2 | TRPA1 antagonists | ABBVIE INC. (US) | 2014-11-04 | — | — | US | disclosed |
| EP-2240450-A1 | TRPA1 ANTAGONISTS | Abbott Laboratories (US) | 2010-10-20 | — | — | EP | disclosed |
| US-20090264480-A1 | TRPA1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-10-22 | — | — | US | disclosed |
| WO-2009089083-A1 | TRPA1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150065538-A1 | TRPA1 ANTAGONISTS | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885JUN 3042/4885NFKB1 1430/4885 |
| US-20090264480-A1 | TRPA1 ANTAGONISTS | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885JUN 3042/4885NFKB1 1430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.