Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL338046 | 0.98 | GAA (0.56) | GAACA1CA2MMP2MMP1 | |
| SCHEMBL3818649 | 0.98 | GAA (0.56) | GAACA1CA2MMP2MMP1 | |
| Propane SCHEMBL3021103 | 0.91 | GAA (0.50) | GAACA1CA2MMP2MMP1 | |
| SCHEMBL3016245 | 0.87 | GAA (0.46) | GAACA1CA2MMP2MMP1 | |
| Thiocyanic Acid SCHEMBL8512493 | 0.84 | GAA (0.43) | GAACA1CA2MMP2MMP1 | |
| Chlorobenzene SCHEMBL3023979 | 0.84 | ALDH1A1 (0.47) | GAACA1CA2CA12CA9 | |
| Benzenethiol SCHEMBL8487581 | 0.82 | CA12 (0.43) | GAACA1CA2MMP2MMP1 | |
| SCHEMBL7949872 | 0.82 | CYP2C19 (0.42) | GAACA1CA2MMP2MMP1 | |
| Thiosulfuric Acid SCHEMBL28402065 | 0.81 | GAA (0.54) | GAACA1CA2MMP2MMP1 | |
| Potassium SCHEMBL30108988 | 0.80 | GAA (0.59) | GAACA1CA2MMP2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3831841-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T Global Inc. (US) | 2021-06-09 | — | — | EP | disclosed |
| US-20190151403-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. | 2019-05-23 | — | — | US | disclosed |
| EP-3458470-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T Global Inc. (US) | 2019-03-27 | — | — | EP | disclosed |
| US-10077241-B2 | Tetrahydro-benzoimidazolyl modulators of TGR5 | JANSEN PHARMACEUTICA NV (BE) | 2018-09-18 | — | — | US | disclosed |
| WO-2017200984-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. (US) | 2017-11-23 | — | — | WO | disclosed |
| US-20170101445-A1 | NOVEL CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF A VIRAL INFECTION | S&T GLOBAL INC. | 2017-04-13 | — | — | US | disclosed |
| US-9573978-B2 | Cyclosporin derivatives for the treatment and prevention of a viral infection | S&T GLOBAL, INC. (US) | 2017-02-21 | — | — | US | disclosed |
| US-20170029381-A1 | TETRAHYDRO-BENZOIMIDAZOLYL MODULATORS OF TGR5 | JANSSEN PHARMACEUTICA NV (BE) | 2017-02-02 | — | — | US | disclosed |
| US-20160052972-A1 | NOVEL CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF A VIRAL INFECTION | S&T GLOBAL INC. | 2016-02-25 | — | — | US | disclosed |
| US-9217015-B2 | Cyclosporin derivatives for the treatment and prevention of a viral infection | S&T GLOBAL INC. (US) | 2015-12-22 | — | — | US | disclosed |
| US-6306863-B1 | TREATMENT OF ASTHMA WITH CAMPOUNDS | ASTRAZENECA AB (SE) | 2001-10-23 | — | — | US | disclosed |
| US-6229013-B1 | PRODUCED BY HYDROGENATION AND DEHALOGENATION IN THE PRESENCE OF A CATALYST; ANTIINFLAMMATORY AGENTS, IMMUNOSUPRESSANTS, ANTIPROLIFERATIVE AGENTS, ANTICARCINOGENIC AGENTS, AND TREATMENT OF RHEUMATIC DISEASE | ASTRAZENECA UK LIMITED (GB) | 2001-05-08 | — | — | US | disclosed |
| US-6211368-B1 | HYDROLYSIS OF CORRESPONDING ESTER | ASTRAZENECA UK LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| US-6180635-B1 | NOVEL THIENO(2,3-D)PYRIMIDINEDIONES WHICH EXHIBIT PHARMACOLOGICAL ACTIVITY, IN PARTICULAR IMMUNOSUPPRESSIVE ACTIVITY; TREATING ALLOGRAFT REJECTION | ASTRAZENECA UK LIMITED (GB) | 2001-01-30 | — | — | US | disclosed |
| US-6166206-A | Pyrrolo[3,4-D]Pyrimidinone derivatives and their use as medicaments | ASTRAZENECA UK LIMITED (GB) | 2000-12-26 | — | — | US | disclosed |
| US-6046204-A | Pyrrolo[3,4-D] pyrimidinone derivatives and their use as medicaments | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-04-04 | — | — | US | disclosed |
| US-6028074-A | FOR TREATING ALLOGRAFT REJECTION | ASTRA PHARMACEUTICALS, LTD. (GB) | 2000-02-22 | — | — | US | disclosed |
| EP-0495253-B1 | Method for the photographic production of silver images | AGFA GEVAERT NV (BE) | 1995-05-10 | — | — | EP | disclosed |
| US-5266442-A | Method for increasing the contrast of photographic silver images | AGFA-GEVAERT N.V. (BE) | 1993-11-30 | — | — | US | disclosed |
| EP-0495253-A1 | Method for the photographic production of silver images | AGFA-GEVAERT N.V. (BE) | 1992-07-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052972-A1 | NOVEL CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF A VIRAL INFECTION | HAVCR2, TSLP, ICOS | GAA 1885/4885CA1 2950/4885CA2 1240/4885 |
| US-20190151403-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | MALT1, MYLK2, FKBP1B | GAA 2720/4885CA1 4153/4885CA2 1322/4885 |
| US-10077241-B2 | Tetrahydro-benzoimidazolyl modulators of TGR5 | GLRA1, GRM5, TRHR | GAA 3306/4885CA1 4132/4885CA2 3845/4885 |
| US-20170029381-A1 | TETRAHYDRO-BENZOIMIDAZOLYL MODULATORS OF TGR5 | GLRA1, GRM5, TRHR | GAA 3306/4885CA1 4132/4885CA2 3845/4885 |
| US-20170101445-A1 | NOVEL CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF A VIRAL INFECTION | HAVCR2, TSLP, HLA-DRB1 | GAA 1815/4885CA1 2992/4885CA2 1103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.