Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 12/20 | 0.49 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.42 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7860101 | 0.87 | ADRA2A (0.46) | NISCHMAOAMAOBADRA2AADRA2B | |
| SCHEMBL3169171 | 0.84 | NISCH (0.52) | NISCHMAOAMAOBADRA2AADRA2B | |
| SCHEMBL7859921 | 0.79 | ADRA2B (0.46) | NISCHMAOAMAOBADRA2AADRA2B | |
| SCHEMBL7854333 | 0.79 | ADRA2B (0.46) | NISCHMAOAMAOBADRA2AADRA2B | |
| SCHEMBL3163294 | 0.78 | WDR5 (0.57) | NISCHMAOAMAOBADRA1AADRA1D | |
| SCHEMBL7854564 | 0.77 | ADRA2A (0.47) | NISCHMAOAMAOBADRA2AADRA2B | |
| SCHEMBL7861399 | 0.77 | ADRA2A (0.47) | NISCHMAOAMAOBADRA2AADRA2B | |
| SCHEMBL7861283 | 0.77 | ADRA2A (0.50) | NISCHMAOAMAOBADRA2AADRA2B | |
| SCHEMBL7861142 | 0.77 | ADRA2A (0.50) | NISCHMAOAMAOBADRA2AADRA2B | |
| SCHEMBL9440693 | 0.76 | NISCH (0.52) | NISCHMAOAMAOBADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173720-A2 | 2-IMIDAZOLINES HAVING A GOOD AFFINITY TO THE TRACE AMINE ASSOCIATED RECEPTORS (TAARS) | F. Hoffmann-Roche AG (CH) | 2010-04-14 | — | — | EP | claimed |
| WO-2009003868-A2 | 2 -IMIDAZOLINES HAVING A GOOD AFFINITY TO THE TRACE AMINE ASSOCIATED RECEPTORS (TAARS) | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-08 | — | — | WO | claimed |