Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CUL4A | Q13619 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7102277 | 0.85 | ALDH1A1 (0.40) | ALDH1A1KDM4EPDE4DSOAT1L3MBTL1 | |
| SCHEMBL2592014 | 0.85 | PDE4D (0.42) | ALDH1A1KDM4EPDE4DSOAT1L3MBTL1 | |
| SCHEMBL10964577 | 0.80 | HCAR3 (0.45) | ALDH1A1PDE4DSOAT1L3MBTL1NPSR1 | |
| SCHEMBL6630708 | 0.80 | ALOX5 (0.38) | ALDH1A1KDM4EPDE4DSOAT1L3MBTL1 | |
| SCHEMBL10673565 | 0.76 | GAA (0.49) | L3MBTL1ALPLNPC1MAPTRAB9A | |
| SCHEMBL3164864 | 0.72 | ALDH1A1 (0.41) | ALDH1A1KDM4EPDE4DSOAT1KMT2A | |
| SCHEMBL8719841 | 0.71 | PKM (0.48) | ALDH1A1KDM4EPDE4DSOAT1KMT2A | |
| SCHEMBL7973627 | 0.71 | ALDH1A1 (0.48) | ALDH1A1SOAT1L3MBTL1KMT2AMEN1 | |
| SCHEMBL377046 | 0.71 | HCAR2 (0.32) | — | |
| SCHEMBL3824624 | 0.69 | ALDH1A1 (0.41) | ALDH1A1KDM4ESOAT1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176264-B1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES FOR TREATING HEMATOLOGICAL DISORDERS | BAYER IP GMBH (DE) | 2012-12-19 | — | — | EP | disclosed |
| EP-2176264-A1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AND THEIR USE | Bayer Schering Pharma AG (DE) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009007029-A1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-01-15 | — | — | WO | disclosed |