SCHEMBL3677950

SCHEMBL3677950

COc1ccc(CC2=CC(=O)NC2=O)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.51
KMT2A Q03164 5/20 0.51
NSD2 O96028 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
LTA4H P09960 1/20 0.46
CMA1 P23946 1/20 0.42
SAE1 Q9UBE0 1/20 0.41
UBA2 Q9UBT2 1/20 0.41
ERAP1 Q9NZ08 1/20 0.41
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
ALDH1A1 P00352 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
GAA P10253 1/20 0.40
GSK3A P49840 1/20 0.40
GSK3B P49841 1/20 0.40
IDO1 P14902 1/20 0.40
MAPT P10636 1/20 0.40
IDH1 O75874 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9508340 0.86 MAOA (0.35) MEN1KMT2ANSD2L3MBTL1MAOA
SCHEMBL3673529 0.84 MAPT (0.46) L3MBTL1ALDH1A1SMN1; SMN2GAAMAPT
SCHEMBL3675112 0.81 DAO (0.41) ALDH1A1SMN1; SMN2IDO1MAPT
SCHEMBL3684146 0.81 SRD5A2 (0.47) MEN1KMT2ANSD2L3MBTL1LTA4H
SCHEMBL1542665 0.80 CA2 (0.56) MEN1KMT2AALDH1A1MAPT
SCHEMBL4804512 0.77 ESR1 (0.46) ALDH1A1GSK3BIDH1
SCHEMBL3791542 0.77 CYP3A4 (0.46) KMT2AL3MBTL1MAOAMAOBALDH1A1
SCHEMBL94148 0.77 MAOA (0.48) MEN1KMT2AMAOAMAOBSMN1; SMN2
Ammonia Solution, Strong SCHEMBL27962960 0.75 MAOA (0.47) MEN1KMT2AMAOAMAOBSMN1; SMN2
Ethylene SCHEMBL28271283 0.74 MAOA (0.46) MEN1KMT2AMAOAMAOBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7825188-B2 Thermoplastic elastomer with acyloxyphenyl hard block segment DESIGNER MOLECULES, INC. (US) 2010-11-02 US claimed
WO-2008077141-A1 RUBBER EPOXY CURATIVES AND METHODS FOR USE THEREOF DESIGNER MOLECULES, INC. (US) 2008-06-26 WO claimed
US-20080146738-A1 RUBBER EPOXY CURATIVES AND METHODS FOR USE THEREOF DESIGNER MOLECULES, INC. 2008-06-19 US claimed
CN-114213309-A Method for preparing maleimide 苏州昊帆生物股份有限公司 2022-03-22 CN disclosed
US-7825188-B2 Thermoplastic elastomer with acyloxyphenyl hard block segment DESIGNER MOLECULES, INC. (US) 2010-11-02 US disclosed
WO-2008077141-A1 RUBBER EPOXY CURATIVES AND METHODS FOR USE THEREOF DESIGNER MOLECULES, INC. (US) 2008-06-26 WO disclosed
US-20080146738-A1 RUBBER EPOXY CURATIVES AND METHODS FOR USE THEREOF DESIGNER MOLECULES, INC. 2008-06-19 US disclosed
EP-1373494-A2 SUCCINIMIDE AND MALEIMIDE DERIVATIVES AND THEIR USE AS TOPOISOMERASE II CATALYTIC INHIBITORS Topo Target A/S (DK) 2004-01-02 EP disclosed
WO-2002078679-A2 SUCCINIMIDE AND MALEIMIDE DERIVATIVES AND THEIR USE AS TOPOISOMERASE II CATALYTIC INHIBITORS TOPO TARGET APS (DK) 2002-10-10 WO disclosed
CN-1009006-B Thermosetting resin composition, and prepreg and laminated sheet material produced from the same HITACHI LTD (JP) 1990-08-01 CN disclosed