SCHEMBL3678465

SCHEMBL3678465

CCc1c(N)c(N)c2cccc(Cl)c2c1CC

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 3/20 0.38
CYP1A2 P05177 2/20 0.37
CYP2A6 P11509 2/20 0.37
ALDH1A1 P00352 3/20 0.35
KDM4E B2RXH2 3/20 0.35
MAPK1 P28482 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
TAAR1 Q96RJ0 1/20 0.34
GAA P10253 2/20 0.34
HSP90AB1 P08238 1/20 0.34
CHEK1 O14757 1/20 0.33
FLT3 P36888 1/20 0.33
PLK3 Q9H4B4 1/20 0.33
ACHE P22303 2/20 0.32
BCHE P06276 1/20 0.32
CDK5 Q00535 1/20 0.31
CDK5R1 Q15078 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3674644 0.79 HKDC1 (0.39) ALDH1A1KDM4E
SCHEMBL3676167 0.79 ALDH1A1 (0.35) CYP1A2ALDH1A1KDM4ETAAR1GAA
SCHEMBL3670998 0.72 ACHE (0.35) CYP1A2ALDH1A1KDM4EMAPK1GAA
SCHEMBL3675001 0.72 ALDH1A1 (0.47) NR4A2CYP1A2CYP2A6ALDH1A1KDM4E
SCHEMBL3670118 0.72 KDM4E (0.37) CYP1A2CYP2A6ALDH1A1KDM4EMAPK1
SCHEMBL3678466 0.70 NR4A2 (0.37) NR4A2ALDH1A1KDM4EGAALMNA
SCHEMBL91356 0.69 TAAR1 (0.50) CYP1A2CYP2A6ALDH1A1KDM4ETAAR1
SCHEMBL29701394 0.69 ALDH1A1 (0.52) NR4A2ALDH1A1KDM4EMAPK1TAAR1
SCHEMBL3791097 0.69 ALDH1A1 (0.52) NR4A2ALDH1A1KDM4EMAPK1TAAR1
SCHEMBL12143410 0.67 GPR17 (0.42) GAACHEK1CDK5CDK5R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1426392-B1 COMPOSITION FOR OPTICAL MATERIAL MITSUBISHI GAS CHEMICAL CO (JP) 2010-02-24 EP disclosed
US-6960640-B2 Composition for optical material MITSUBISHI GAS CHEMICAL CO., LTD. (JP) 2005-11-01 US disclosed
US-20040147708-A1 Composition for optical material MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-07-29 US disclosed
EP-1426392-A1 COMPOSITION FOR OPTICAL MATERIAL MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-06-09 EP disclosed