Pr-104

Pr-104

SCHEMBL367963

CS(=O)(=O)OCCN(CCBr)c1c(C(=O)NCCOP(=O)(O)O)cc([N+](=O)[O-])cc1[N+](=O)[O-]

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.36
MEN1 O00255 5/20 0.36
HPGD P15428 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
NPC1 O15118 4/20 0.33
RAB9A P51151 1/20 0.32
LMNA P02545 3/20 0.32
MAPT P10636 2/20 0.32
GAA P10253 1/20 0.32
HKDC1 Q2TB90 1/20 0.32
HTT P42858 2/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
POLB P06746 1/20 0.31
CYP3A4 P08684 1/20 0.31
FLT1 P17948 1/20 0.31
FLT4 P35916 1/20 0.31
KDR P35968 1/20 0.31
MAPK1 P28482 1/20 0.30
ALDH1A1 P00352 1/20 0.30
PRMT5 O14744 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pr-104 SCHEMBL31060232 1.00 KMT2A (0.36) KMT2AMEN1HPGDNPSR1NPC1
SCHEMBL13338201 0.92 TDP1 (0.38) KMT2AMEN1HPGDNPSR1NPC1
SCHEMBL3422264 0.92 KMT2A (0.36) KMT2AMEN1HPGDNPSR1NPC1
SCHEMBL3418938 0.92 KMT2A (0.36) KMT2AMEN1HPGDNPSR1NPC1
SCHEMBL3589344 0.91 KMT2A (0.40) KMT2AMEN1HPGDNPSR1NPC1
SCHEMBL13338135 0.90 KMT2A (0.38) KMT2AMEN1HPGDNPSR1NPC1
SCHEMBL366334 0.90 KMT2A (0.38) KMT2AMEN1HPGDNPSR1NPC1
SCHEMBL29468020 0.90 KMT2A (0.38) KMT2AMEN1HPGDNPSR1NPC1
SCHEMBL3420379 0.90 MEN1 (0.33) KMT2AMEN1HPGDNPSR1NPC1
SCHEMBL13338209 0.88 KMT2A (0.36) KMT2AMEN1HPGDNPSR1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 170 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240374566-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER LANKENAU INST FOR MEDICAL RESESARCH (US) 2024-11-14 US claimed
EP-4176876-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER Lankenau Institute for Medical Research (US) 2023-05-10 EP claimed
CN-115927619-A System for leukemia diagnosis and treatment 杭州赫玛生物科技有限公司 2023-04-07 CN claimed
CN-115927622-A System for leukemia diagnosis and treatment 杭州赫玛生物科技有限公司 2023-04-07 CN claimed
CN-115927621-A System for leukemia diagnosis and treatment 杭州赫玛生物科技有限公司 2023-04-07 CN claimed
CN-115927620-A System for leukemia diagnosis and treatment 杭州赫玛生物科技有限公司 2023-04-07 CN claimed
CN-108937848-B System for leukemia diagnosis and treatment 赫玛超生物科技(上海)有限公司 2022-12-09 CN claimed
EP-3681498-B1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER LANKENAU INST MEDICAL RES (US) 2022-10-05 EP claimed
US-20220249522-A1 Hypoxia Targeting Compositions and Combinations Thereof with a PARP Inhibitor and Methods of Use Thereof THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2022-08-11 US claimed
EP-2858974-B9 LIPIDS FOR THERAPEUTIC AGENT DELIVERY FORMULATIONS NITTO DENKO CORP (JP) 2022-07-20 EP claimed
US-20100121091-A1 Processes of preparing asymmetric dinitrobenzamide mustard compounds, intermediate compounds useful therein and products obtained therefrom AUCKLAND UNISERVICES LIMITED (NZ) 2010-05-13 US claimed
US-20100010094-A1 Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents AUCKLAND UNISERVICES LIMITED (NZ) 2010-01-14 US claimed
US-7629332-B2 Nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents AUCKLAND UNISERVICES LIMITED (NZ) 2009-12-08 US claimed
WO-2008033039-A1 CANCER TREATMENT PATTERSON ADAM VORN (NZ) 2008-03-20 WO claimed
US-20080064665-A1 Combination approaches to cancer treatment AUCKLAND UNISERVICES LIMITED (NZ) 2008-03-13 US claimed
US-20070032455-A1 Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents AUCKLAND UNIVERVICES LIMITED (NZ) 2007-02-08 US claimed
EP-4724077-A1 COMBINATION OF BACTERIAL STRAINS TO INHIBIT PATHOGENS IN ANIMALS Phibro Animal Health Corporation (US) 2026-04-15 EP disclosed
US-20260062578-A1 IMAGE FORMING METHOD, IMAGE FORMING APPARATUS, IMAGE, AND INKJET INK KONICA MINOLTA INC (JP) 2026-03-05 US disclosed
US-20080064665-A1 Combination approaches to cancer treatment AUCKLAND UNISERVICES LIMITED (NZ) 2008-03-13 US disclosed
US-20070032455-A1 Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents AUCKLAND UNIVERVICES LIMITED (NZ) 2007-02-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260062578-A1 IMAGE FORMING METHOD, IMAGE FORMING APPARATUS, IMAGE, AND INKJET INK ACIN1, ILK, KRT18 KMT2A 3140/4885MEN1 3175/4885HPGD 4101/4885
US-20080064665-A1 Combination approaches to cancer treatment NPM1, NOX3, TYRO3 KMT2A 2479/4885MEN1 2798/4885HPGD 1481/4885
US-20100121091-A1 Processes of preparing asymmetric dinitrobenzamide mustard compounds, intermediate compounds useful therein and products obtained therefrom HRH2, HRH4, H1-2 KMT2A 75/4885MEN1 2521/4885HPGD 1510/4885
US-20070032455-A1 Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents NAPRT, NTPCR, PNP KMT2A 1372/4885MEN1 3896/4885HPGD 109/4885
US-20100010094-A1 Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents NAPRT, NTPCR, QDPR KMT2A 1079/4885MEN1 3811/4885HPGD 111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.