Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 11/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19138009 | 0.97 | HTT (0.46) | DHODHHTTHSD17B10PDE10ALMNA | |
| SCHEMBL14917460 | 0.85 | MEN1 (0.47) | HTTHSD17B10IKBKBCDK5CDK5R1 | |
| SCHEMBL27779234 | 0.85 | CDK5 (0.50) | HTTHSD17B10LMNATSHRCDK5 | |
| SCHEMBL27332910 | 0.83 | HTT (0.59) | HTTHSD17B10CDK5CDK5R1 | |
| SCHEMBL9351900 | 0.80 | PTGS1 (0.51) | HTTHSD17B10LMNA | |
| SCHEMBL28459405 | 0.77 | KDM4E (0.50) | DHODHPDE10ALMNATSHRNAPRT | |
| SCHEMBL9047986 | 0.77 | ADORA2A (0.48) | MAP4K4 | |
| SCHEMBL8936345 | 0.77 | KMO (0.54) | HTTHSD17B10 | |
| SCHEMBL27843373 | 0.77 | CDK5 (0.45) | HTTHSD17B10LMNACDK5CDK5R1 | |
| SCHEMBL5532401 | 0.76 | DHODH (0.49) | DHODHPDE10ALMNATSHRNAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120014918-A1 | ADDITION SALTS OF AMINES CONTAINING HYDROXYL AND/OR CARBOXYLIC GROUPS WITH AMINO NICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | ALMIRALL, S.A. (ES) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120014918-A1 | ADDITION SALTS OF AMINES CONTAINING HYDROXYL AND/OR CARBOXYLIC GROUPS WITH AMINO NICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | DHODH, DAO, ADH1B | DHODH 1/4885HTT 1078/4885HSD17B10 230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.