Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 7/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6141505 | 0.80 | DHFR (0.36) | HSD11B1HRH3MEN1KMT2APOLB | |
| SCHEMBL5618972 | 0.79 | MEN1 (0.43) | HSD11B1HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL30065877 | 0.79 | ALDH1A1 (0.50) | MAOBALDH1A1 | |
| SCHEMBL2968461 | 0.79 | ALDH1A1 (0.50) | MAOBALDH1A1 | |
| SCHEMBL29232281 | 0.78 | KDM4E (0.38) | HSD11B1MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL27445640 | 0.78 | HSD11B1 (0.41) | HSD11B1MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL3685410 | 0.78 | MAOB (0.43) | HSD11B1HRH3MEN1KMT2AMAOB | |
| SCHEMBL4119366 | 0.77 | MAOB (0.40) | HSD11B1MEN1KMT2AMAOBALDH1A1 | |
| SCHEMBL6908438 | 0.77 | GAA (0.41) | HSD11B1MEN1KMT2APOLBKDM4E | |
| SCHEMBL3688257 | 0.76 | ALDH1A1 (0.51) | MEN1KMT2APOLBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |